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KMID : 0616620000060020271
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Journal of Soonchunhyang Medical College
2000 Volume.6 No. 2 p.271 ~ p.275
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Cross positivity among specific mite antigens in allergic rhinitis patients
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Abstract
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The current study was designed to evaluate the positive rates of arthropod allergens by Korean inhalant panel of MAST-CLA in patients with allergic rhinitis. One hundred sixty patients, diagnosed to allergic rhinitis in an Out Patient Center of Soonchunhyang University Chunan Hopsital during Aug 1998 to July 2000, were studied.
1.The overall positive rate among 35 specific allergens was 59.4% (95 patients).
2.The arthropod related allergen accounted for 82.1% (78 patients) of the positive rate.
3.Each positive rate of Dermatophagoides farinae (Df), Dermatophagoides pteronyssinus (Dp), house dust (Hd), and cockroach mix (Cm) was 45.0 % (72 patients), 43.1 % (69 patients), 28.1 % (45 patients), and 8.8 % (14 patients), respectively.
4.Significant agreement between arthropod allergens was observed (P < 0.05).
5.The obseved agreement between Df and Dp was 95.6 %, showing most significant Kappa index (Kappa = 0.911, P < 0.001).
These results suggested that although MAST-CLA is a useful measure of identifying specific allergens, the specificity of two mite allergen is relatively low, implying because of common allergen between mites in Korean panel of MAST-CLA. Our data also supported that arthropod is the major cause of allergen in patients with allergic rhinitis, however, the MAST-CLA should be modified in order to exclude common allergen of mite and to include more specific mite allergen.
Key words : arthropod, allergen, allergic rhinitis, MAST-CLA
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